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No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals.

Neurobiology of aging - 1 Feb 2014

Bi Rui, Zhao Liansheng, Zhang Chen, Lu Weihong, Feng Jia-Qi, Wang Yingcheng, Ni Jianliang, Zhang Jiangtao, Li Guo-Dong, Hu Qiu-Xiang, Wang Dong, Yao Yong-Gang, Li Tao

Abstract excerpt

The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independent cohorts from southwestern China (341 AD patients and 435 normal individuals) and eastern China (297 AD patients...

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PMID: 24080176
DOI: 10.1016/j.neurobiolaging.2013.08.013

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