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Article

Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029

3 May 2017

Abstract excerpt

The cloning of microbial natural product biosynthetic gene clusters and their heterologous expression in a suitable host have proven to be a feasible approach to improve the yield of valuable natural products and to begin mining cryptic natural products in microorganisms. Myxobacteria are a prolific source of novel bioactive natural products with only limited choices of heterologous hosts that have been...

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PMID: 28467833
DOI: 10.1021/acschembio.7b00097

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