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Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases.

ACS chemical biology - 18 Jan 2013

Koryakina Irina, McArthur John, Randall Shan, Draelos Matthew M, Musiol Ewa M, Muddiman David C, Weber Tilmann, Williams Gavin J

Abstract excerpt

Polyketide synthases construct polyketides with diverse structures and biological activities via the condensation of extender units and acyl thioesters. Although a growing body of evidence suggests that polyketide synthases might be tolerant to non-natural extender units, in vitro and in vivo studies aimed at probing and utilizing polyketide synthase specificity are severely limited to only a small number of...

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Acyltransferases
Bacterial Proteins
Chromatography, Liquid
Coenzyme A Ligases
Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Models, Molecular

Substrate Specificity

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PMID: 23083014
DOI: 10.1021/cb3003489

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