Article
The hematopoietic transcription factor PU.1 regulates RANK gene expression in myeloid progenitors.
Biochemical and biophysical research communications - 23 Sept 2005
Kwon Oh Hyung, Lee Chong-Kil, Lee Young Ik, Paik Sang-Gi, Lee Hyun-Jun
Abstract excerpt
Osteoclasts are bone resorbing cells of hematopoietic origin. The hematopoietic transcription factor PU.1 is critical for osteoclastogenesis; however, the molecular mechanisms of PU.1-regulated osteoclastogenesis have not been explored. Here, we present evidence that the receptor activator of nuclear factor kappaB (RANK) gene that has been shown to be crucial for osteoclastogenesis is a transcriptional target of...
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