Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Oct 2006

Rossa Carlos, Ehmann Kathryn, Liu Min, Patil Chetan, Kirkwood Keith L

Abstract excerpt

Coupled bone turnover is directed by the expression of receptor-activated NF-kappaB ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Proinflammatory cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) induce RANKL expression in bone marrow stromal cells. Here, we report that IL-1beta and TNF-alpha-induced RANKL requires p38 mitogen-activating protein kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Imidazoles
Share to Interleukin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

Share to Osteoclasts

Share to p38 Mitogen-Activated Protein Kinases

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Stromal Cells

Source

Identifiers

PMID: 17032166
DOI: 10.1089/jir.2006.26.719

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells.PMID 17032166Read ↗

Role of RANKL Signaling in Bone HomeostasisSemantic proximity Read ↗

Biology of the RANKLâ€“RANKâ€“OPG System in Immunity, Bone, and BeyondSemantic proximity Read ↗

Receptor Activator of Nuclear Factor-κB Ligand Activates Nuclear Factor-κB in Osteoclast Precursors*Semantic proximity Read ↗

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossSemantic proximity Read ↗

Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B.Semantic proximity Read ↗

RANKL and RANK in Cancer TherapySemantic proximity Read ↗

Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells.Semantic proximity Read ↗

p38 MAPK Regulates IL‐1β Induced IL‐6 Expression Through mRNA Stability in OsteoblastsSemantic proximity Read ↗

IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)Semantic proximity Read ↗

Regulatory roles and molecular signaling of TNF family members in osteoclastsSemantic proximity Read ↗

Historically significant events in the discovery of RANK/RANKL/OPGSemantic proximity Read ↗

The alterations of molecular repertoire of the RANKL-induced osteoclastogenesis in the M1 macrophage-derived inflammatory milieuSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.