Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PU.1 and NFATc1 mediate osteoclastic induction of the mouse β<sub>3</sub> integrin promoter

20 Feb 2008

Abstract excerpt

Expression of the alpha(v)beta(3) integrin is required for normal osteoclast function. We previously showed that an evolutionary conserved NFATc1 binding site is required for RANKL induction and NFATc1 transactivation of the human beta(3) promoter. The mechanism conferring specificity for RANKL induction and NFATc1 transduction of the beta(3) gene in osteoclast differentiation is unclear since NFATc1 is expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Cell Adhesion Molecules Research
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18288635
DOI: 10.1002/jcp.21344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PU.1 and NFATc1 mediate osteoclastic induction of the mouse β<sub>3</sub> integrin promoterPMID 18288635Read ↗

NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation.Semantic proximity Read ↗

MITF and PU.1 Recruit p38 MAPK and NFATc1 to Target Genes during Osteoclast DifferentiationSemantic proximity Read ↗

Autoamplification of NFATc1 expression determines its essential role in bone homeostasisSemantic proximity Read ↗

Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.Semantic proximity Read ↗

NFATc1: Functions in osteoclastsSemantic proximity Read ↗

Osteoclast differentiation and gene regulationSemantic proximity Read ↗

Transcriptional regulation of bone and joint remodeling by NFATSemantic proximity Read ↗

MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCARSemantic proximity Read ↗

Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B.Semantic proximity Read ↗

Mitf regulates osteoclastogenesis by modulating NFATc1 activitySemantic proximity Read ↗

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesisSemantic proximity Read ↗

Activation of NFAT Signal In Vivo Leads to Osteopenia Associated with Increased Osteoclastogenesis and Bone-Resorbing ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.