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Article

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function.

The Journal of biological chemistry - 15 Nov 2002

Armstrong Allison P, Tometsko Mark E, Glaccum Moira, Sutherland Claire L, Cosman David, Dougall William C

Abstract excerpt

Signaling through receptor activator of nuclear factor-kappaB (RANK) is essential for the differentiation and activation of osteoclasts, the cell principally responsible for bone resorption. Animals genetically deficient in RANK or the cognate RANK ligand are profoundly osteopetrotic because of t...

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Source

Identifiers

PMID: 12185073
DOI: 10.1074/jbc.M202009200

Genes

TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12185073-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function.PMID 12185073Read ↗

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.Semantic proximity Read ↗

RANK is essential for osteoclast and lymph node development.Semantic proximity Read ↗

RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesisSemantic proximity Read ↗

Expression Profile of RhoGTPases and RhoGEFs During RANKL-Stimulated Osteoclastogenesis: Identification of Essential Genes in OsteoclastsSemantic proximity Read ↗

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The role of osteoclast differentiation and function in skeletal homeostasisSemantic proximity Read ↗

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in <i>TRAF6</i>‐deficient miceSemantic proximity Read ↗

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.Semantic proximity Read ↗

Historically significant events in the discovery of RANK/RANKL/OPGSemantic proximity Read ↗

Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B.Semantic proximity Read ↗

Characterization of a spontaneous osteopetrosis model using RANKL-dysfunctional mice.Semantic proximity Read ↗

A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage.Semantic proximity Read ↗

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