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Article

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.

1 Mar 1993

Abstract excerpt

The myeloid integrin CD11b is expressed selectively on the surface of mature monocytes, macrophages, granulocytes, and natural killer cells. Tissue-specific and developmentally regulated expression of CD11b is controlled at the level of mRNA transcription, and recent characterization of the human CD11b promoter indicates that the first 92 bp of 5'-flanking DNA are sufficient to direct tissue-specific expression...

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PMID: 8095266
DOI: 10.1016/s0021-9258(18)53496-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.PMID 8095266Read ↗

Characterization of the myeloid-specific CD11b promoterSemantic proximity Read ↗

CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.Semantic proximity Read ↗

The Zinc Finger Transcription Factor Transforming Growth Factor β-Inducible Early Gene-1 Confers Myeloid-specific Activation of the Leukocyte Integrin CD11d PromoterSemantic proximity Read ↗

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution.Semantic proximity Read ↗

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.Semantic proximity Read ↗

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

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PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates.Semantic proximity Read ↗

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