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Article

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2005

Schröder Nicolas W J, Diterich Isabel, Zinke Antje, Eckert Jana, Draing Christian, von Baehr Volker, Hassler Dieter, Priem Susanne, Hahn Katrin, Michelsen Kathrin S, Hartung Thomas, Burmester Gerd R, Göbel Ulf B, Hermann Corinna, Schumann Ralf R

Abstract excerpt

Lyme disease (LD) is caused by Borrelia burgdorferi and displays different stages, including localized, early disseminated, and persistent infection, all of which are associated with profound inflammatory reactions in the host. Induction of proinflammatory cytokines by B. burgdorferi is mainly mediated by outer surface proteins interacting with TLR-2/TLR-1 heterodimers. In this study, we show that TNF-alpha...

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PMID: 16081826
DOI: 10.4049/jimmunol.175.4.2534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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