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Article

The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis.

The Journal of allergy and clinical immunology - 1 Apr 2008

Mrabet-Dahbi Salima, Dalpke Alexander H, Niebuhr Margarete, Frey Markus, Draing Christian, Brand Stephanie, Heeg Klaus, Werfel Thomas, Renz Harald

Abstract excerpt

BACKGROUND: Impaired host defense mechanisms may crucially modulate the pathogenesis of atopic dermatitis (AD). More than 10% of patients with AD are heterozygous for the Toll-like receptor 2 (TLR-2) R753Q single nucleotide polymorphism (SNP) and exhibit severe eczema. OBJECTIVE: To elucidate the functional effect of the TLR-2 mutation and its putative relevance for AD. METHODS: Using the human embryonic kidney...

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Source

Identifiers

PMID: 18234309
DOI: 10.1016/j.jaci.2007.11.029

Genes

LTA
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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