Article

A primate specific loss of function polymorphism in TLR2 gene decreases inflammation and protects humans from organ dysfunction in Malaria

2017-12-24

Abstract excerpt

Polymorphisms of TLR genes could regulate and contribute functionally to innate immunity and inflammation. TLR2, a promiscous receptor recognizes Pathogen Associated Molecular Patterns from several microbes, bacterial, viral, protozoan and helminths. We demonstrate that monocytes of humans with deletion polymorphism in TLR2 gene (a 23 bp deletion in 5’ UTR region) respond more vigorously in vitro to several TLR2...

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Literature Corpus work: e4ead4df-8b0b-5875-966d-570dc9cea981
DOI: 10.1101/239129

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