Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic instability and chromosomal instability in hepatocellular carcinoma.

The American journal of pathology - 1 Apr 2006

Katoh Hiroto, Shibata Tatsuhiro, Kokubu Akiko, Ojima Hidenori, Fukayama Masashi, Kanai Yae, Hirohashi Setsuo

Abstract excerpt

The aim of this study was to clarify the association between the epigenetic instability phenotype and the chromosomal instability phenotype in primary hepatocellular carcinoma (HCC). Sixty primary HCC tumors were examined. Methylation status for nine CpG islands (the p16, COX2, GSTP1, RASSF1A, E-cadherin, and APC gene promoters, and the MINT 1, 25, and 31 clones) was evaluated by methylation-specific polymerase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Hepatitis A

Share to Hepatitis B

Share to Liver Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 16565510
DOI: 10.2353/ajpath.2006.050989
PMCID: PMC2216681

Genes

APC
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic instability and chromosomal instability in hepatocellular carcinoma.PMID 16565510Read ↗

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomasSemantic proximity Read ↗

Genetic Instability and Aberrant Dna Methylation in Chronic Hepatitis and Cirrhosis—A Comprehensive Study of Loss of Heterozygosity and Microsatellite Instability At 39 Loci and Dna Hypermethylation on 8 Cpg Islands in Microdissected Specimens From Patients With Hepatocellular CarcinomaSemantic proximity Read ↗

Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis.Semantic proximity Read ↗

Chromosomal instability and human hepatocarcinogenesis.Semantic proximity Read ↗

Oxidative Stress and Epigenetic Instability in Human HepatocarcinogenesisSemantic proximity Read ↗

Clinical implications of DNA methylation in hepatocellular carcinoma.Semantic proximity Read ↗

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomasSemantic proximity Read ↗

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridizationSemantic proximity Read ↗

Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas.Semantic proximity Read ↗

p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survivalSemantic proximity Read ↗

Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma.Semantic proximity Read ↗

Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.