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Hepcidin and DNA promoter methylation in hepatocellular carcinoma

13 Dec 2017

Abstract excerpt

BACKGROUND: The liver hormone hepcidin regulates iron homoeostasis that is often altered in hepatocellular carcinoma (HCC). Epigenetic phenomena control gene expression through a dynamic fashion; therefore, considering the plasticity of both iron homoeostasis and epigenetic mechanisms and their role in liver carcinogenesis, we investigated whether hepcidin gene (HAMP) expression is modulated by DNA methylation,...

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PMID: 29235098
DOI: 10.1111/eci.12870

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