Article
p16 promoter hypermethylation in human hepatocellular carcinoma with or without hepatitis virus infection.
Intervirology - 1 Jan 2004
Narimatsu Takashi, Tamori Akihiro, Koh Noritoshi, Kubo Shoji, Hirohashi Kazuhiro, Yano Yoshihisa, Arakawa Tetsuo, Otani Shuzo, Nishiguchi Shuhei
Abstract excerpt
BACKGROUND: Epigenetic alteration through methylation is one of the most important steps in carcinogenesis. However, the relation between hepatitis virus infection and epigenetic alterations is poorly understood. METHODS: Sixteen patients without hepatitis B virus (HBV) and hepatitis C virus (HCV...
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