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Article

DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.

Journal of biomedical science - 1 Mar 2008

Guo Zhanjun, Tsai Mong-Hsun, Shiao Yih-Horng, Chen Li-Han, Wei Mei-Ling, Lv Xing, Gius David, Little John B, Mitchell James B, Chuang Eric Y

Abstract excerpt

In cancer, gene silencing via hypermethylation is as common as genetic mutations in p53. Understanding the relationship between mutant p53 and hypermethylation of other tumor suppressor genes is essential when elucidate mechanisms of tumor development. In this study, two isogenic human B lymphoblast cell lines with different p53 status include TK6 containing wild-type p53 and WTK1 with mutant p53 were used and...

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Source

Identifiers

PMID: 18038118
DOI: 10.1007/s11373-007-9222-y

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.PMID 18038118Read ↗

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