Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

31 Jan 2014

Abstract excerpt

The polo-like kinase (PLKs) family, consisting of five known members, are key regulators of important cell cycle processes, which include mitotic entry, centrosome duplication, spindle assembly, and cytokinesis. The PLKs have been implicated in a variety of cancers, such as hepatocellular carcinoma (HCC), with PLK1 typically overexpressed and PLKs 2-5 often downregulated. Altered expression of the PLKs in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24498222
DOI: 10.1371/journal.pone.0087918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative StressPMID 24498222Read ↗

Epigenetic Inactivation Implies a Tumor Suppressor Function in Hematologic Malignancies for Polo-Like Kinase 2 but not Polo-Like Kinase 3Semantic proximity Read ↗

Present and Future Perspective on PLK1 Inhibition in Cancer TreatmentSemantic proximity Read ↗

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence?Semantic proximity Read ↗

Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functionsSemantic proximity Read ↗

Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in miceSemantic proximity Read ↗

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.Semantic proximity Read ↗

Plk1-mediated phosphorylation of Topors regulates p53 stability.Semantic proximity Read ↗

Beyond DNA Repair: DNA-PK Function in CancerSemantic proximity Read ↗

p53 and its downstream proteins as molecular targets of cancerSemantic proximity Read ↗

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?Semantic proximity Read ↗

The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor MetastasisSemantic proximity Read ↗

Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.