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Article

CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma.

International journal of cancer - 1 Sept 2008

Zhang Changsong, Guo Xianling, Jiang Guocheng, Zhang Li, Yang Yang, Shen Feng, Wu Mengchao, Wei Lixin

Abstract excerpt

CpG island methylator phenotype (CIMP) involves the targeting of multiple genes by promoter hypermethylation. Telomerase plays an important role in the development of cellular immortality and oncogenesis. To gain insight into the role of epigenetic aberration of telomerase-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in HCC. We examined the promoter methylation status of 9 genes...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18546260
DOI: 10.1002/ijc.23650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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