Article
Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis.
The Journal of rheumatology - 1 Aug 2005
Gonzalez-Gay Miguel A, Oliver Javier, Orozco Gisela, Garcia-Porrua Carlos, Lopez-Nevot Miguel A, Martin Javier
Abstract excerpt
OBJECTIVE: To assess the possible association between PTPN22 1858C(R)T polymorphism and susceptibility to giant cell arteritis (GCA) and to determine if this polymorphism is implicated in the clinical expression of this vasculitis. METHODS: Ninety-six patients with biopsy-proven GCA and 229 ethnically matched controls from the Lugo region of Northwest Spain were studied using molecular methods. All individuals...
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