Article
A somatically mutated V kappa IV gene encoding a human rheumatoid factor light chain.
Clinical and experimental immunology - 1 Jun 1992
Gause A, Küppers R, Mierau R
Abstract excerpt
The light chain of an IgA kappa rheumatoid factor (RF) produced by a hybridoma derived from a patient with rheumatoid arthritis (RA) has been shown to belong to the V kappa IV family. This RF light chain has 31 nucleotide differences compared with the single V kappa IV germline gene reported for...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA
- Humans
- Immunoglobulin A
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Rheumatoid Factor