Article
Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.
The Journal of clinical investigation - 1 Jun 1994
Deftos M, Olee T, Carson D A, Chen P P
Abstract excerpt
A major diagnostic marker in most rheumatoid arthritis (RA) patients is the rheumatoid factor (RF), an autoantibody that binds to the Fc region of IgG. To delineate the Ig genes and the underlying mechanism for RF production in RA patients, we applied a systematic approach to define the genetic origins of three IgG RFs derived from the synovial fluid of two RA patients. The results show that two of three IgG RF...
Topics
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data