Article
Persistence of a rheumatoid factor (RF)-producing B cell clone with a somatically mutated Ig kappa chain in a patient with rheumatoid arthritis.
Clinical and experimental immunology - 1 Aug 1994
Schrauder A, Gause A, Jung W, Mierau R, Pfreundschuh M
Abstract excerpt
The V kappa IV gene encoding the light chain of an IgA has been shown to have undergone 31 somatic mutations compared with the single existing V kappa IV germ-line gene. We now show the persistence of the rearranged and mutated DNA coding for this RF over a period of 5 years in the peripheral blo...
Topics
- Arthritis, Rheumatoid
- B-Lymphocytes
- Base Sequence
- Clone Cells
- Cloning, Molecular
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Humans
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Rheumatoid Factor