Article
A minor group of rheumatoid factors isolated from a patient with rheumatoid arthritis is derived from somatically mutated Vk1 genes further evidence that rheumatoid factors during autoimmune diseases undergo an antigen driven maturation.
Autoimmunity - 1 Jan 1993
Martin T, Crouzier R, Blaison G, Levallois H, Pasquali J L
Abstract excerpt
To better understand the structural basis for rheumatoid factor [RF] activity and the origin of autoantibodies in human autoimmune diseases, we isolated the RF producing B cells from the peripheral blood and from the synovial fluid of a patient suffering from rheumatoid arthritis [RA]. We previou...
Topics
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Rheumatoid Factor