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Article

Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1992

Randen I, Brown D, Thompson K M, Hughes-Jones N, Pascual V, Victor K, Capra J D, Førre O, Natvig J B

Abstract excerpt

Using hybridoma technology we established a panel of human monoclonal rheumatoid factors (RF) from the synovial tissues of two patients with rheumatoid arthritis (RA), and one patient with polyarticular juvenile RA. Nucleotide sequence analysis of the V regions of these RF indicates that two independently derived antibodies from one of the RA patients are clonally related. One of these antibodies appears to be...

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PMID: 1578151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue.PMID 1578151Read ↗

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