Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1992

Randen I, Brown D, Thompson K M, Hughes-Jones N, Pascual V, Victor K, Capra J D, Førre O, Natvig J B

Abstract excerpt

Using hybridoma technology we established a panel of human monoclonal rheumatoid factors (RF) from the synovial tissues of two patients with rheumatoid arthritis (RA), and one patient with polyarticular juvenile RA. Nucleotide sequence analysis of the V regions of these RF indicates that two inde...

Topics

Amino Acid Sequence
Antibody Affinity
Arthritis, Rheumatoid
Base Sequence
Humans
Immunoglobulin M
Molecular Sequence Data
Mutation
Rheumatoid Factor
Synovial Membrane

Source

Open in PubMed

Identifiers

PMID: 1578151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1578151-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics