Article
Immunoglobulin V genes in rheumatoid arthritis.
Rheumatic diseases clinics of North America - 1 Nov 1992
Sasso E H
Abstract excerpt
Recent studies have revealed that a broad spectrum of Ig V genes (VH, V kappa, V lambda) contribute to the rheumatoid factor (RF) and non-RF produced by B cells in patients with rheumatoid arthritis (RA). This result contrasts with the restricted V gene use of paraprotein IgM RF. Certain VH and VL genes, however, appear more often in RA than expected from random expression, including some of the...
Topics
- Arthritis, Rheumatoid
- Genes
- Genetic Predisposition to Disease
- Humans
- Immunoglobulin Idiotypes
- Immunoglobulin Variable Region
- Immunoglobulins
- Polymorphism, Genetic
- Reference Values
- Rheumatoid Factor