Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated.

doi:10.1172/JCI117040

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Article

Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated.

The Journal of clinical investigation - 1 Feb 1994

Youngblood K, Fruchter L, Ding G, Lopez J, Bonagura V, Davidson A

Abstract excerpt

We report the DNA sequences of the heavy and light chain immunoglobulin genes of 11 monoclonal rheumatoid factor (RF)-secreting lines derived from the peripheral blood of two patients with rheumatoid arthritis (RA). It is evident from immunogenetic analysis of these lines that RA-associated RF activity can arise from a wide variety of heavy and light chain genes and gene combinations. Although the RF response...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Arthritis, Rheumatoid
B-Lymphocytes
Base Sequence
Cell Line
Epitopes
Genes, Immunoglobulin
Humans
Immunoglobulin Fc Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Immunoglobulin Light Chains

Immunoglobulin kappa-Chains

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 7509350
DOI: 10.1172/JCI117040
PMCID: PMC293948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7509350-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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