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Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity

21 Jul 2005

Abstract excerpt

We have previously identified in the pol gene of human immunodeficiency virus type 1 (HIV-1) a new positive transcriptional regulatory element (nt 4481-4982) containing recognition sites for nuclear proteins (sites B, C, D and a GC-box) [C. Van Lint, J. Ghysdael, P. Paras, Jr, A. Burny and E. Verdin (1994) J. Virol. 68, 2632-2648]. In this study, we have further physically characterized each binding site and have...

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PMID: 16061936
DOI: 10.1093/nar/gki720

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