Article
Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals: application to HIV-1 INS.
Nucleic acids research - 1 Jun 2003
Wolff Horst, Brack-Werner Ruth, Neumann Markus, Werner Thomas, Schneider Ralf
Abstract excerpt
Regulation of gene expression involves sequence elements in nucleic acids. In promoters, multiple sequence elements cooperate as functional modules, which in combination determine overall promoter activity. We previously developed computational tools based on this hierarchical structure for in silico promoter analysis. Here we address the functional organization of post-transcriptional control elements, using the...
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