Article
cis-Acting Sequences Located Downstream of the Human Immunodeficiency Virus Type 1 Promoter Affect Its Chromatin Structure and Transcriptional Activity
1 Jun 1996
Abstract excerpt
We have examined the roles of AP-1, AP-3-like, DBF1, and Sp1 binding sites, which are located downstream of the human immunodeficiency virus type 1 (HIV-1) promoter, in regulating basal transcriptional activity directed by the integrated viral long terminal repeat (LTR). Point mutations affecting all four of these elements functionally inactivated the HIV-1 LTR when it was constrained in a chromatin...
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