Article
Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I.
Virology journal - 16 May 2014
Shah Sonia, Alexaki Aikaterini, Pirrone Vanessa, Dahiya Satinder, Nonnemacher Michael R, Wigdahl Brian
Abstract excerpt
BACKGROUND: HIV-1 gene expression is driven by the long terminal repeat (LTR), which contains many binding sites shown to interact with an array of host and viral factors. Selective pressures within the host as well as the low fidelity of reverse transcriptase lead to changes in the relative prevalence of genetic variants within the HIV-1 genome, including the LTR, resulting in viral quasispecies that can be...
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