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Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.

Cancer research - 15 May 2006

Fenske Timothy S, McMahon Christine, Edwin Deepa, Jarvis Joseph C, Cheverud James M, Minn Matthew, Mathews Vikram, Bogue Molly A, Province Michael A, McLeod Howard L, Graubert Timothy A

Abstract excerpt

Secondary malignancies are a serious adverse consequence of alkylator chemotherapy. The risk of developing an alkylator-associated malignancy is influenced by genetic background, although the relevant genetic factors are poorly understood. To screen for novel susceptibility factors, we established a mouse model of alkylator-induced malignancy. We exposed mice from 20 inbred strains to the prototypical alkylating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16707424
DOI: 10.1158/0008-5472.CAN-05-3404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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