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Article

Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.

Arthritis and rheumatism - 1 Aug 2005

Delano David L, Montesinos M Carmen, Desai Avani, Wilder Tuere, Fernandez Patricia, D'Eustachio Peter, Wiltshire Tim, Cronstein Bruce N

Abstract excerpt

OBJECTIVE: Low-dose methotrexate (MTX), a mainstay in the treatment of rheumatoid arthritis, is effective in only 60-70% of patients, a finding mirrored by poor antiinflammatory efficacy in some animal models, most notably collagen-induced arthritis. To determine whether genetic factors or the model itself is responsible for the poor response to MTX, we directly compared the responses of 4 inbred mouse strains to...

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Identifiers

PMID: 16059892
DOI: 10.1002/art.21208
PMCID: PMC1343510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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