Article
Analysis of candidate genes of spontaneous arthritis in mice deficient for interleukin-1 receptor antagonist.
Genes & genetic systems - 1 Jan 2012
Cao Yanhong, Li Caijuan, Yan Jian, Jiao Feng, Liu XiaoYun, Hasty Karen A, Stuart John M, Gu Weikuan, Jiao Yan
Abstract excerpt
Previously, we identified a major quantitative trait locus (QTL) on mouse chromosome 1 that regulates the susceptibility to arthritis in an F2 population generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin-1 receptor antagonist. To further select candidate genes for the QTL, we analyzed the expression patterns of arthritis in 38 F2 individuals and compared the...
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