Article

Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis

2023-11-28

Abstract excerpt

<title>Abstract</title> <p>Background CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint. Although low dose methotrexate (MTX) is clinically used to treat RA patients, CXCL12 signaling responses to MTX-mediated treatments is still controversial. Methods In this study, we examined the expression of CXCR4...

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Literature Corpus work: b5bf9233-fe8f-54d8-91dc-27529bbb32b2
DOI: 10.21203/rs.3.rs-3649330/v1

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