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Article

Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.

Arthritis and rheumatism - 1 Sept 2006

Wessels Judith A M, Kooloos Wouter M, De Jonge Robert, De Vries-Bouwstra Jeska K, Allaart Cornelia F, Linssen Annelies, Collee Gerard, De Sonnaville Peter, Lindemans Jan, Huizinga Tom W J, Guchelaar Henk-Jan

Abstract excerpt

OBJECTIVE: Among patients with rheumatoid arthritis (RA), there is a high degree of interindividual variability in the degree of response to methotrexate (MTX) treatment. This study was undertaken to explore polymorphisms in genes contributing to antiinflammatory adenosine release as novel predictors of MTX treatment outcome. METHODS: In 205 patients with newly diagnosed RA, 5 polymorphisms in 5 genes coding for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Arthritis, Rheumatoid

Share to Gene Expression Regulation, Enzymologic

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Source

Identifiers

PMID: 16947783
DOI: 10.1002/art.22032

Genes

ATIC
AMPD1
ITPA
MTR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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