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Article

The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.

G3 (Bethesda, Md.) - 7 Aug 2013

Kislukhin Galina, King Elizabeth G, Walters Kelli N, Macdonald Stuart J, Long Anthony D

Abstract excerpt

The severity of the toxic side effects of chemotherapy varies among patients, and much of this variation is likely genetically based. Here, we use the model system Drosophila melanogaster to genetically dissect the toxicity of methotrexate (MTX), a drug used primarily to treat childhood acute lym...

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Identifiers

PMID: 23733889
DOI: 10.1534/g3.113.006619
PMCID: PMC3737169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23733889-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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