Article

Mechanistic insights into glucocorticoid-induced ocular hypertension using differences in mouse strain responsiveness

2025-07-05

Abstract excerpt

Glucocorticoids (GCs) are widely prescribed anti-inflammatory agents. Unfortunately, many people experience negative side-effects associated with long term GC therapy, developing GC-induced ocular hypertension (GC-OHT), which can lead to secondary glaucoma. Approximately, 40% of the treated individuals are susceptible to GC-OHT. Seventy years since this discovery, the molecular mechanisms underlying GC-OHT remain...

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Literature Corpus work: 864f6110-4a1b-5d13-aea2-cf2c6bbc15e0
DOI: 10.1101/2025.07.02.662542

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