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Article

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.

Pharmacogenetics and genomics - 1 Dec 2009

Dervieux Thierry, Wessels Judith A M, van der Straaten Tahar, Penrod Nadia, Moore Jason H, Guchelaar Henk-Jan, Kremer Joel M

Abstract excerpt

OBJECTIVE: As no single nucleotide polymorphism has emerged as pivotal to predict the lack of efficacy and dose-limiting toxicities to methotrexate (MTX), we evaluated the contribution of gene-gene interactions to the effects of this prodrug in rheumatoid arthritis. METHODS: A total of 255 patien...

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Share to Adenosine
Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biosynthetic Pathways

Share to Epistasis, Genetic

Share to Folic Acid

Share to Methotrexate

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19858780
DOI: 10.1097/FPC.0b013e32833315d1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19858780-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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