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Article

Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data.

American journal of human genetics - 1 Feb 2002

Douglas Julie A, Skol Andrew D, Boehnke Michael

Abstract excerpt

Gene-mapping studies routinely rely on checking for Mendelian transmission of marker alleles in a pedigree, as a means of screening for genotyping errors and mutations, with the implicit assumption that, if a pedigree is consistent with Mendel's laws of inheritance, then there are no genotyping errors. However, the occurrence of inheritance inconsistencies alone is an inadequate measure of the number of...

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Identifiers

PMID: 11791214
DOI: 10.1086/338919
PMCID: PMC419989

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