A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data.

doi:10.1086/302861

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data.

American journal of human genetics - 1 Apr 2000

Douglas J A, Boehnke M, Lange K

Abstract excerpt

The identification of genes contributing to complex diseases and quantitative traits requires genetic data of high fidelity, because undetected errors and mutations can profoundly affect linkage information. The recent emphasis on the use of the sibling-pair design eliminates or decreases the likelihood of detection of genotyping errors and marker mutations through apparent Mendelian incompatibilities or close...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Gene Frequency
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genotype
Haplotypes
Humans
Lod Score
Markov Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matched-Pair Analysis

Models, Genetic

Mutation

Nuclear Family

Research Design

Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 10739757
DOI: 10.1086/302861
PMCID: PMC1288195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10739757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data.PMID 10739757Read ↗

Comparative study of multipoint methods for genotype error detection.Semantic proximity Read ↗

Simultaneous estimation of genotype error and uncalled deletion rates in whole genome sequence dataSemantic proximity Read ↗

Identification and analysis of error types in high-throughput genotyping.Semantic proximity Read ↗

Detection and integration of genotyping errors in statistical genetics.Semantic proximity Read ↗

Detection of Mendelian consistent genotyping errors in pedigrees.Semantic proximity Read ↗

Integration of SNP genotyping confidence scores in IBD inference.Semantic proximity Read ↗

Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data.Semantic proximity Read ↗

Simultaneous estimation of genotype error and uncalled deletion rates in whole genome sequence data.Semantic proximity Read ↗

Accounting for linkage in family-based tests of association with missing parental genotypes.Semantic proximity Read ↗

Detecting low-quality markers using map expanders.Semantic proximity Read ↗

The impact of genotyping error on family-based analysis of quantitative traits.Semantic proximity Read ↗

An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: implications for study design.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.