Article
Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2005
Mohan Subburaman, Kapoor Anil, Singgih Anny, Zhang Zhang, Taylor Tim, Yu Hongrun, Chadwick Robert B, Chung Yoon-Sok, Chung Yoon-Suk, Donahue Leah Rae, Rosen Clifford, Crawford Grace C, Wergedal Jon, Baylink David J
Abstract excerpt
UNLABELLED: Using a mouse mutant that fractures spontaneously and dies at a very young age, we identified that a deletion of the GULO gene, which is involved in the synthesis of vitamin C, is the cause of impaired osteoblast differentiation, reduced bone formation, and development of spontaneous fractures. INTRODUCTION: A major public health problem worldwide, osteoporosis is a disease characterized by inadequate...
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