Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mef2c deletion in osteocytes results in increased bone mass.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2012

Kramer Ina, Baertschi Stefan, Halleux Christine, Keller Hansjoerg, Kneissel Michaela

Abstract excerpt

Myocyte enhancer factors 2 (MEF2) are required for expression of the osteocyte bone formation inhibitor Sost in vitro, implying these transcription factors in bone biology. Here, we analyzed the in vivo function of Mef2c in osteocytes in male and female mice during skeletal growth and aging. Dmp1-Cre-induced Mef2c deficiency led to progressive decreases in Sost expression by 40% and 70% in femoral cortical bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Bone Resorption

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Lumbar Vertebrae

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Osteocytes

Source

Identifiers

PMID: 22161640
DOI: 10.1002/jbmr.1492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mef2c deletion in osteocytes results in increased bone mass.PMID 22161640Read ↗

Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.Semantic proximity Read ↗

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.Semantic proximity Read ↗

Targeted deletion of <i>Sost</i> distal enhancer increases bone formation and bone massSemantic proximity Read ↗

Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice.Semantic proximity Read ↗

Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.Semantic proximity Read ↗

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone RemodelingSemantic proximity Read ↗

Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasisSemantic proximity Read ↗

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone HomeostasisSemantic proximity Read ↗

Control of the <i>SOST</i> Bone Enhancer by PTH Using MEF2 Transcription FactorsSemantic proximity Read ↗

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton.Semantic proximity Read ↗

Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in miceSemantic proximity Read ↗

Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.