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Article

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia

24 Mar 2017

Abstract excerpt

Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived congenital anomalies. Increasing evidence in Fanconi anemia and other genetic disorders points towards an interdependence of skeletal and hematopoietic development, yet the impact of the marrow microenvironment in the pathogenesis of the bone...

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Identifiers

PMID: 28341737
DOI: 10.3324/haematol.2016.158717

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