Article
Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.
Journal of cellular physiology - 1 Jul 2013
Abdeen Suhaib K, Del Mare Sara, Hussain Sadeeq, Abu-Remaileh Muhannad, Salah Zaidoun, Hagan John, Rawahneh Maysoon, Pu Xin-An, Russell Stacey, Stein Janet L, Stein Gary S, Lian Jane B, Aqeilan Rami I
Abstract excerpt
WW domain-containing oxidoreductase (WWOX) is highly conserved in both human and murine. WWOX spans the second most common human chromosomal fragile site, FRA16D, and is commonly inactivated in multiple human cancers. Modeling WWOX inactivation in mice revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in...
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