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Article

A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2005

Jiao Yan, Li Xinmin, Beamer Wesley G, Yan Jian, Tong Yiai, Goldowitz Daniel, Roe Bruce, Gu Weikuan

Abstract excerpt

Map-based cloning is an iterative approach that identifies the underlying genetic cause of a mutant phenotype. However, the classic protocol of positional cloning is time-consuming and labor-intensive. We now describe a genome sequence-based cloning approach that has led to localizing the underlying genetic cause of spontaneous fractures (sfx) in a mouse model. The sfx/sfx mouse is characterized by a spontaneous...

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PMID: 15674730
DOI: 10.1007/s00335-004-2414-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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