Article
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Biochemical and biophysical research communications - 29 Jun 1998
Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T, Sato Y, Nakagawa N, Yasuda H, Mochizuki S, Gomibuchi T, Yano K, Shima N, Washida N, Tsuda E, Morinaga T, Higashio K, Ozawa H
Abstract excerpt
Osteoclasts are multinucleated cells that resorb bone. Osteoclastogenesis inhibitory factor (OCIF), also called osteoprotegerin (OPG), acts as a naturally occurring decoy receptor for osteoclast differentiation factor, which mediates an essential signal to osteoclast progenitors for their differe...
Topics
- Animals
- Bone Density
- Bone and Bones
- Cell Differentiation
- Disease Models, Animal
- Femur
- Gene Targeting
- Glycoproteins
- Histocytochemistry
- Mice
- Mice, Knockout
- Osteoclasts
- Osteoporosis
- Osteoprotegerin