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Article

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.

Molecular and cellular biology - 1 Aug 2005

Saleh-Gohari Nasrollah, Bryant Helen E, Schultz Niklas, Parker Kayan M, Cassel Tobias N, Helleday Thomas

Abstract excerpt

Homologous recombination is vital to repair fatal DNA damage during DNA replication. However, very little is known about the substrates or repair pathways for homologous recombination in mammalian cells. Here, we have compared the recombination products produced spontaneously with those produced following induction of DNA double-strand breaks (DSBs) with the I-SceI restriction endonuclease or after stalling or...

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Identifiers

PMID: 16055725
DOI: 10.1128/MCB.25.16.7158-7169.2005
PMCID: PMC1190269

Genes

RAD51
SSB
XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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