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The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells

25 Oct 2007

Abstract excerpt

The mammalian ERCC1-XPF endonuclease has a suggested role in the repair of DNA double-strand breaks (DSB) by single-strand annealing (SSA). Here, we investigated the role of ERCC1 in homologous recombination in mammalian cells, and confirm a role of ERCC1 in SSA. Interestingly, we also report an unexpected role for ERCC1 in gene conversion. This provides support that gene conversion in mammalian somatic cells is...

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PMID: 17962301
DOI: 10.1093/nar/gkm888

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Related research

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The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cellsPMID 17962301Read ↗

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cellsSemantic proximity Read ↗

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

The formation of UV-induced chromosome aberrations involves ERCC1 and XPF but not other nucleotide excision repair genes.Semantic proximity Read ↗

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.Semantic proximity Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.Semantic proximity Read ↗

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cellsSemantic proximity Read ↗

Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cellsSemantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.Semantic proximity Read ↗

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.Semantic proximity Read ↗

ATRX and RECQ5 define distinct homologous recombination subpathwaysSemantic proximity Read ↗

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