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Article

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.

Genes & development - 15 Dec 1998

Richardson C, Moynahan M E, Jasin M

Abstract excerpt

To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal rearrangements in mammalian cells, we employed an ES cell system to analyze recombination between repeats on heterologous chromosomes. We found that recombination is induced at least 1000-fold following the introduction of a DSB in one repeat. Most (98%)...

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Identifiers

PMID: 9869637
DOI: 10.1101/gad.12.24.3831
PMCID: PMC317271

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