Article
Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.
Genes & development - 15 Dec 1998
Richardson C, Moynahan M E, Jasin M
Abstract excerpt
To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal rearrangements in mammalian cells, we employed an ES cell system to analyze recombination between repeats on heterologous chromosomes. We found th...
Topics
- Alleles
- Animals
- Blotting, Southern
- Cell Line
- Chromosomes
- Crossing Over, Genetic
- DNA Damage
- DNA Repair
- DNA Replication
- Deoxyribonucleases, Type II Site-Specific
- Gene Conversion
- Gene Duplication
- Genes, Reporter
- In Situ Hybridization, Fluorescence
- Mice
- Models, Genetic
- Mutation
- Protein Serine-Threonine Kinases