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Article

Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells.

Molecular and cellular biology - 1 Nov 1997

Taghian D G, Nickoloff J A

Abstract excerpt

Double-strand breaks (DSBs) stimulate chromosomal and extrachromosomal recombination and gene targeting. Transcription also stimulates spontaneous recombination by an unknown mechanism. We used Saccharomyces cerevisiae I-SceI to stimulate recombination between neo direct repeats in Chinese hamster ovary (CHO) cell chromosomal DNA. One neo allele was controlled by the dexamethasone-inducible mouse mammary tumor...

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Identifiers

PMID: 9343400
DOI: 10.1128/MCB.17.11.6386
PMCID: PMC232490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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