Article
Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
Aging cell - 1 Dec 2011
Delaney Joe R, Sutphin George L, Dulken Ben, Sim Sylvia, Kim Jin R, Robison Brett, Schleit Jennifer, Murakami Christopher J, Carr Daniel, An Elroy H, Choi Eunice, Chou Annie, Fletcher Marissa, Jelic Monika, Liu Bin, Lockshon Daniel, Moller Richard M, Pak Diana N, Peng Qi, Peng Zhao J, Pham Kim M, Sage Michael, Solanky Amrita, Steffen Kristan K, Tsuchiya Mitsuhiro, Tsuchiyama Scott, Johnson Simon, Raabe Chris, Suh Yousin, Zhou Zhongjun, Liu Xinguang, Kennedy Brian K, Kaeberlein Matt
Abstract excerpt
Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32 different lifespan-extending mutations and four methods of DR on replicative lifespan (RLS) in the short-lived sir2Δ yeast strain. In every case, deletion of SIR2 prevented RLS extension; however, RLS extension was restored when both SIR2 and FOB1 were deleted in...
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